An 81-Year-Old Patient With Distant Metastasis of Invasive Lobular Carcinoma Occurring 41 Years After Mastectomy - Corrected Proof

Foluso O. Ademuyiwa, Thaer Khoury, John Warner, James Gannon, Helena Hwang — 2012-05-18

Relationship Between Lymphocytopenia and Circulating Tumor Cells as Prognostic Factors for Overall Survival in Metastatic Breast Cancer - Corrected Proof

2012-05-17

Micro-Abstract: We assessed the prognostic significance of lymphocytopenia, circulating tumor cell (CTC) count, and extensive bone metastases in 195 patients with metastatic breast cancer (MBC). In a multivariate analysis, lymphocytopenia ≥ 5 CTCs/7.5 mL of blood, estrogen receptor status, and line of therapy were the only predictive factors for progression-free survival (PFS)and overall survival (OS). CTC measurement and lymphocytopenia are independent prognostic factors in these patients. Abstract: Introduction: Lymphocytopenia and circulating tumor cells (CTCs) have been reported as independent prognostic factors for overall survival (OS) in metastatic breast cancer (MBC), and both have been associated with bone metastases. Our objective was to compare the prognostic significance of lymphocytopenia, CTC count, and extensive bone metastases (> 2 lesions) assessed by fluorine-18 (18F) fluorodeoxyglucose positron emission tomography/computed tomography (FDG–PET/CT) in patients with MBC. Patients and Methods: This is a retrospective study that included patients with MBC who were starting a new line of systemic therapy. The study population consisted of patients treated at the University of Texas MD Anderson Cancer Center between 2004 and 2008 for whom baseline CTC count, lymphocyte counts, and FDG–PET/CT scans were available. Patients were stratified according to estrogen receptor status (positive vs. negative), human epidermal growth factor receptor 2 (HER2) status (amplified vs. constitutive), baseline CTC counts per 7.5 mL of blood (< 5 CTCs/7.5 mL of blood vs. ≥ 5 CTCs/7.5 mL of blood), lymphocytopenia (< 1000 vs. ≥ 1000/μL), and extensive bone metastases (> 2 vs. ≤ 2 lesions). Results: In 195 assessable patients, the median OS was 27 months (range, 1 to > 45 months). In multivariate analysis, lymphocytopenia, ≥ 5 CTCs/7.5 mL of blood, estrogen receptor status, and line of therapy were the only predictive factors for progression-free survival (PFS) (2P = .001, 2P = .032, 2P = .029, and 2P = .002, respectively) and OS (2P = .001, 2P = .009, 2P = .004, and 2P = .024, respectively). Conclusion: CTC measurement and lymphocytopenia are independent prognostic factors for PFS and OS in patients with MBC.

Small-Cell Cancer of the Breast: What Is the Optimal Treatment? A Report and Review of Outcomes - Corrected Proof

2012-04-23

Primary Malignant Fibrous Histiocytoma of the Breast: A Case Report and Review of 38 Chinese Cases - Corrected Proof

Yue Hu, Xiuzhen Li, Yongchuan Deng, Meiqi Zhou, Suzhan Zhang — 2012-04-23

Primary Neuroendocrine Breast Carcinoma - Corrected Proof

2012-04-19

Breast Cancer Presenting Within or Adjacent to the Breast Implant Capsule: A Case Series and Clinical Recommendations - Corrected Proof