Abstract
Background
Mesothelin is an ideal tumor-associated marker for the development of targeted therapy
due to its limited expression in normal tissues. The aim of this study was to evaluate
mesothelin expression in triple-negative breast cancer (TNBC) and its correlation
with survival outcomes.
Methods
Mesothelin expression was completed by using immunohistochemistry and was quantified
by the H score. An H score > 10 was considered positive. Patient characteristics were
compared by mesothelin expression. The Kaplan-Meier product limit method was used
to estimate survival outcomes. Cox proportional hazards models was used to adjust
for patient and tumor characteristics.
Results
The median age was 52 years. Of the 109 patients with TNBC, 37 (34%) were positive
for mesothelin expression. There were no differences on patient and/or tumor characteristics
by mesothelin expression with the exception of high frequency of lymphovascular space
invasion in mesothelin-negative tumors (2P = .03). At a median follow-up of 75.8 months, 20 (18.3%) patients had experienced
a recurrence, and 22 (20.2%) had died. Five-year progression-free survival was 87%
and 92% in patients with mesothelin-positive and those with mesothelin-negative tumors
(2P = .43). Five-year overall survival was 85% and 91% in patients with mesothelin-positive
and those with mesothelin-negative tumors (2P = .57), respectively. Mesothelin expression was not an independent predictor of survival
outcomes.
Conclusion
Mesothelin expression was identified in 34% of patients with TNBC. Mesothelin expression
did not correlate with survival outcomes in patients with TNBC.
Keywords
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Article info
Publication history
Published online: July 01, 2013
Accepted:
May 3,
2013
Received in revised form:
April 29,
2013
Received:
January 11,
2013
Identification
Copyright
© 2013 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
