Abstract
Pertuzumab is a monoclonal antibody that represents the first among a new class of
agents known as human epidermal growth factor receptor (HER) dimerization inhibitors.
This is the first systematic review according to Preferred Reporting Items for Systematic
Reviews and Meta-Analyses guidelines to synthesize all available data of pertuzumab
in breast cancer. The search strategy retrieved 11 studies that evaluated pertuzumab.
One study was conducted in the neoadjuvant setting (417 patients), whereas all the
others dealt with patients with recurrent, metastatic, or refractory disease (1023
patients). Six studies were conducted in HER2+ breast cancer population (1354 patients), whereas 5 studies (86 patients) were conducted
in HER2– (or unknown HER2 status) disease. Pertuzumab is the most recent agent approved by
the US Food and Drug Administration in combination with trastuzumab and docetaxel
for the treatment of patients with HER2+ metastatic breast cancer who have not received prior anti-HER2 therapy or chemotherapy
for metastatic disease. This approval has been based on data from a phase III Clinical
Evaluation of Pertuzumab and Trastuzumab (CLEOPATRA) study. The antitumor activity
with the significant reduction in the risk of progression or death, as reflected upon
the increase of 6.1 months in median progression-free survival, indicates that pertuzumab
may provide an avenue for achieving additional benefit for patients with HER2+. Moreover, pertuzumab seems to have a putative role in the management of patients
with HER2 who are resistant to trastuzumab. The promising role of pertuzumab in the
neoadjuvant and adjuvant settings remains to be further investigated and established
in the future.
Keywords
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Article info
Publication history
Published online: June 28, 2013
Accepted:
May 3,
2013
Received in revised form:
May 1,
2013
Received:
September 19,
2012
Identification
Copyright
© 2013 Elsevier Inc. Published by Elsevier Inc. All rights reserved.
