The link between mantle (chest) radiation for the treatment of pediatric Hodgkin lymphoma
and secondary malignant neoplasms in adulthood, especially breast cancer, has been
known for several years.
1
,
2
,
3
,
4
The elevated risk persists regardless of whether women received only high-dose radiation
or the newer treatment regimen of lower dose radiation combined with chemotherapy
5
; it is highest, however, in those treated in their teens and early twenties with
higher doses of radiation. Currently, survivors undergo annual to semiannual breast
screenings with mammograms or breast magnetic resonance imaging (MRI), or both, similar
to women with BRCA mutations.
6
,
7
,
8
Keywords
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References
- Breast cancer after childhood cancer: a report from the Childhood Cancer Survivor Study.Ann Intern Med. 2004; 141: 590-597
- High risk of breast carcinoma after irradiation of young women with Hodgkin's disease.Cancer. 1997; 79: 1203-1210
- High risk of subsequent neoplasms continues with extended follow-up of childhood Hodgkin's disease: report from the Late Effects Study Group.J Clin Oncol. 2003; 21: 4386-4394
- Breast cancer after treatment of Hodgkin's disease.J Natl Cancer Inst. 1993; 85: 25-31
- Breast cancer following radiotherapy and chemotherapy among young women with Hodgkin Disease.JAMA. 2003; 290: 465-475
- Breast cancer surveillance practices among women previously treated with chest radiation for a childhood cancer.JAMA. 2009; 301: 404-414
- High risk populations identified in Childhood Cancer Survivor Study investigations: implications for risk-based surveillance.J Clin Oncol. 2009; 27: 2405-2414
- Long-term results of screening with magnetic resonance imaging in women with BRCA mutations.Br J Cancer. 2012; 107: 24-30
- Second malignant neoplasms: assessment and strategies for risk reduction.J Clin Oncol. 2012; 30: 3734-3745
- Occurrence of multiple subsequent neoplasms in long-term survivors of childhood cancer: a report from the Childhood Cancer Survivor Study.J Clin Oncol. 2011; 29: 3056-3064
- New insights into the risk of breast cancer in childhood cancer survivors treated with chest radiation: a report from the Childhood Cancer Survivor Study (CCSS) and the Women's Environmental Cancer and Radiation Epidemiology (WECARE) study.J Clin Oncol. 2012; 30 (abstract CRA9513. Available at) (Accessed: July 10, 2013)
- Breast cancer risk after supradiaphragmatic radiotherapy for Hodgkin's lymphoma in England and Wales: a national cohort study.J Clin Oncol. 2012; 30: 2745-2752
- Efficacy of bilateral prophylactic mastectomy in BRCA1 and BRCA2 mutation carriers.J Natl Cancer Inst. 2001; 93: 1633-1637
ClinicalTrials.gov. Tamoxifen in the prevention of breast cancer in Hodgkin's disease survivors. Available at: http://clinicaltrials.gov/show/NCT00165308. Accessed March 12, 2013.
Article info
Publication history
Published online: July 29, 2013
Accepted:
June 11,
2013
Received:
March 25,
2013
Identification
Copyright
Published by Elsevier Inc.
