Breast Cancer Risk Assessment and Screening in Transgender Patients

Published:August 24, 2016DOI:
      Cases of breast cancer have been reported in transgender patients; however, because this occurrence is so rare, no evidence-based screening guidelines exist for this complicated patient population, and there are no formal recommendations for surgery selection in this population.


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        • Conron K.J.
        • Landers S.J.
        • Reisner S.L.
        • et al.
        Sex and gender in the US health surveillance system: a call to action.
        Am J Public Health. 2014; 104: 970-976
        • Conron K.J.
        • Scott G.
        • Stowell G.S.
        • et al.
        Transgender health in Massachusetts: results from a household probability sample of adults.
        Am J Public Health. 2012; 102: 118-122
        • Bazzi A.R.
        • Whorms D.S.
        • King D.S.
        • et al.
        Adherence to mammography screening guidelines among transgender persons and sexual minority women.
        Am J Public Health. 2015; 105: 2356-2358
        • Unger C.A.
        Care of the transgender patient: a survey of gynecologists' current knowledge and practice.
        J Womens Health. 2015; 24: 114-118
        • Sattari M.
        Breast cancer in male-to-female transgender patients: a case for caution.
        Clin Breast Cancer. 2015; 15: e67-e69
        • Gooren L.J.
        • van Trotsenburg M.A.
        • Giltay E.J.
        • et al.
        Breast cancer development in transsexual subjects receiving cross-sex hormone treatment.
        J Sex Med. 2013; 10: 3129-3134
        • Brown G.R.
        Breast cancer in transgender veterans: a ten-case series.
        LGBT Health. 2015; 2: 77-80
        • Gooren L.J.
        Management of female-to-male transgender persons: medical and surgical management, life expectancy.
        Curr Opin Endocrinol Diabetes Obes. 2014; 21: 233-238
        • Shao T.
        • Grossbard M.L.
        • Klein P.
        Breast cancer in female-to-male transsexuals: two cases with a review of physiology and management.
        Clin Breast Cancer. 2011; 11: 417-419
        • Dimitrakakis C.
        • Bondy C.
        Androgens and the breast.
        Breast Cancer Res. 2009; 11: 212
        • Bentz E.K.
        • Pils D.
        • Bilban M.
        • et al.
        Gene expression signatures of breast tissue before and after cross-sex hormone therapy in female-to-male transsexuals.
        Fertil Steril. 2010; 94: 2688-2696
        • Phillips J.
        • Fein-Zachary V.J.
        • Mehta T.S.
        • et al.
        Breast imaging in the transgender patient.
        AJR Am J Roentgenol. 2014; 202: 1149-1156
        • Veronesi P.
        • De Lorenzi F.
        • Loschi P.
        • et al.
        Current trends in the oncologic and surgical managements of breast cancer in women with implants: incidence, diagnosis, and treatment.
        Aesthetic Plast Surg. 2016; 40: 256-265
        • Nikolic D.V.
        • Djordjevic M.L.
        • Granic M.
        • et al.
        Importance of revealing a rare case of breast cancer in a female to male transsexual after bilateral mastectomy.
        World J Surg Oncol. 2012; 10: 280
        • Burcombe R.J.
        • Makris A.
        • Pittam M.
        • et al.
        Breast cancer after bilateral subcutaneous mastectomy in a female-to-male trans-sexual.
        Breast. 2003; 12: 290-293
        • Bevers T.B.
        Breast cancer prevention: an update of the STAR trial.
        Curr Treat Options Oncol. 2010; 11: 66-69
        • Fentiman I.S.
        Male breast cancer is not congruent with the female disease.
        Crit Rev Oncol Hematol. 2016; 101: 119-124
        • Tice J.A.
        • Cummings S.R.
        • Smith-Bindman R.
        • et al.
        Using clinical factors and mammographic breast density to estimate breast cancer risk: development and validation of a new predictive model.
        Ann Intern Med. 2008; 148: 337-347
        • James P.A.
        • Doherty R.
        • Harris M.
        • et al.
        Optimal selection of individuals for BRCA mutation testing: a comparison of available methods.
        J Clin Oncol. 2006; 24: 707-715
        • Tyrer J.
        • Duffy S.W.
        • Cuzick J.
        A breast cancer prediction model incorporating familial and personal risk factors.
        Stat Med. 2004; 23: 1111-1130
        • Saslow D.
        • Boetes C.
        • Burke W.
        • et al.
        American Cancer Society guidelines for breast screening with MRI as an adjunct to mammography.
        CA Cancer J Clin. 2007; 57: 75-89
        • Oeffinger K.C.
        • Fontham E.T.
        • Etzioni R.
        • et al.
        Breast cancer screening for women at average risk: 2015 guideline update from the American Cancer Society.
        JAMA. 2015; 314: 1599-1614
        • Smith R.A.
        • Saslow D.
        • Sawyer K.A.
        • et al.
        American Cancer Society guidelines for breast cancer screening: update 2003.
        CA Cancer J Clin. 2003; 53: 141-169