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BRCA2 Reversion Mutation Associated With Acquired Resistance to Olaparib in Estrogen Receptor-positive Breast Cancer Detected by Genomic Profiling of Tissue and Liquid Biopsy

Published:December 20, 2017DOI:https://doi.org/10.1016/j.clbc.2017.12.010
      Inactivating mutations in BRCA1 or BRCA2 predict response to PARP inhibitors and platinum-based chemotherapeutics. However, acquired secondary reversion mutations in BRCA1/2 that underlie resistance to these therapies have been identified in multiple tumor types.

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