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Breast Cancer and Secondary Cancer Recurrences After Autologous Tissue Reconstruction

  • Amy P. Early
    Correspondence
    Address for correspondence: Amy P. Early, MD, Roswell Park Comprehensive Cancer Center, Roswell Park Amherst Center, 100 College Pkwy, Buffalo, NY 14221
    Affiliations
    Department of Medical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY
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  • Wong Moon
    Affiliations
    Department of Plastic & Reconstructive Surgery, Roswell Park Comprehensive Cancer Center, Buffalo, NY
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Published:August 03, 2020DOI:https://doi.org/10.1016/j.clbc.2020.07.015

      Abstract

      Background

      The medical literature defining breast cancer recurrence and secondary cancers after autologous tissue reconstruction for breast cancer is sparse. We sought to identify and analyze occurrences at our institution.

      Patients and Methods

      A 20-year retrospective review of cancer recurrences and atypical breast neoplasms after autologous tissue breast reconstruction at Roswell Park Comprehensive Cancer Center was conducted after being granted a waiver from the institutional review board.

      Results

      Eighteen locoregional recurrences among 337 cases were identified and analyzed. Overall recurrence rate was 5.3%. Four secondary cancers (1.2%) were radiation-induced angiosarcoma, undifferentiated pleomorphic sarcoma, and metaplastic carcinoma. One case of flat epithelial atypia was identified.

      Conclusion

      Our retrospective review found incidence and survival after treatment of breast cancer concordant with reports in the literature. We also identified and analyzed secondary neoplasms, including a unique case of undifferentiated pleomorphic sarcoma and metachronous recurrence of breast carcinoma. A case of recurrence as metaplastic carcinoma was identified.

      Keywords

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