Advertisement

Breast Cancer and the Male-Female Divide: It's Even More Complicated

      Breast cancer in men has traditionally been reported to have a worse prognosis than breast cancer in women. Such conclusion was based on the later stage at diagnosis as well as older age commonly observed in men with breast cancer. Lack of early detection and disparities in treatment were believed to be responsible for worse outcomes. Several earlier studies reported similar stage-specific survival when comparing male to female breast cancer. Hence, the consensus was that male and female breast cancer were biologically similar, and that gender should not be considered a predictor of survival apart from stage of presentation and patient age. One study further suggested improved disease-specific survival in male breast cancer.
      • El-Tamer MB
      • Komenaka IK
      • Troxel A
      • et al.
      Men with breast cancer have better disease-specific survival than women.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Clinical Breast Cancer
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • El-Tamer MB
        • Komenaka IK
        • Troxel A
        • et al.
        Men with breast cancer have better disease-specific survival than women.
        Arch Surg. 2004; 139: 1079-1082https://doi.org/10.1001/archsurg.139.10.1079
        • Gnerlich JL
        • Deshpande AD
        • Jeffe DB
        • Seelam S
        • Kimbuende E
        • Margenthaler JA.
        Poorer survival outcomes for male breast cancer compared with female breast cancer may be attributable to in-stage migration.
        Ann Surg Oncol. 2011; 18: 1837-1844https://doi.org/10.1245/s10434-010-1468-3
        • Wang F
        • Shu X
        • Meszoely I
        • et al.
        Overall mortality after diagnosis of breast cancer in men vs women.
        JAMA Oncol. 2019; 5: 1589-1596https://doi.org/10.1001/jamaoncol.2019.2803
        • Aggarwal A
        • Adepoju B
        • Yacur M
        • Maron D
        • Sharma MC
        Gender disparity in breast cancer: a veteran population-based comparison.
        Clin Breast Cancer. 2021; https://doi.org/10.1016/j.clbc.2021.01.013