Abstarct
Methods and Materials
From July 2006 to December 2015, 295 patients suitable for breast-conserving therapy
entered a single-arm phase II study and were treated with IOERT as radical treatment.
Inclusion criteria were age >50, postmenopausal status, cT1N0M0 stage, grade G1-G2,
positive estrogen receptor status; unicentric and unifocal disease, histologically
proven invasive ductal carcinoma no previous breast irradiation, good performance
status.
Results
With a median follow-up of 7.1 years (95% CI, 6.5;7.4) 6 women (2.0%) experienced
a true local recurrence (reappearance of the tumour in the same quadrant). Five-year
overall survival and local recurrence-free survival were 96% (95% CI, 92.9;97.8) and
94.9% (95% CI, 91.6;97.0) respectively.
Conclusion
Our trial suggests that, in highly selected early stage breast cancers, a single-dose
IOERT can be safely delivered with excellent results and very low long-term recurrence
rates.
Keywords
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Article info
Publication history
Published online: June 10, 2021
Accepted:
May 29,
2021
Received in revised form:
May 24,
2021
Received:
November 26,
2020
Identification
Copyright
© 2021 Elsevier Inc. All rights reserved.
