Abstract
Triple negative breast cancer (TNBC) represents 15% to 20% of all primary breast cancers
and is the most aggressive subtype of breast cancer. There has been rapid progress
in targeted therapy and biomarker development to identify the optimal treatments for
TNBC.
To update recent developments, this article comprehensively reviews molecular classification
and biomarkers of TNBC and targeted therapy developments in immunotherapy, PARP and
AKT pathway inhibitors, antibody-drug conjugates and androgen receptor blockade.
The treatment of TNBC has dramatically evolved beyond basic cytotoxic chemotherapy
into an expanding domain of targeted therapies tailored to the heterogeneity of this
complex and aggressive disease. Progress will continue through the sustained and devoted
efforts of our investigators and the patients who dedicatedly enroll in clinical trials.
Through a daring persistence to challenge the status quo we now have the opportunity
to offer our patients with TNBC a new sense of hope.
Keywords
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Article info
Publication history
Published online: September 16, 2021
Accepted:
September 11,
2021
Received in revised form:
September 1,
2021
Received:
June 16,
2021
Footnotes
All authors contribute equally
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