Abstract
Background
Despite an aging population, there are no established treatment guidelines for women
with ductal carcinoma in situ (DCIS) age ≥80. Here we describe national treatment
patterns and survival outcomes in older women with DCIS.
Patients and Methods
Women age ≥80 diagnosed with DCIS from 2005 to 2014 were identified using the National
Cancer Database. χ2, Fisher's exact test, and logistic regression models were used
to identify factors influencing receipt of breast surgery, and Kaplan-Meier method
and Cox proportional hazard models were used to evaluate overall survival (OS).
Results
A total of 6,070 women with DCIS met inclusion criteria, of which the majority (98%)
received surgery. Receipt of surgery was independently associated with age <90. OS
was higher for those who received surgery compared to those who did not (HR 2.2 [1.72-2.83]
P < .001).
Conclusion
The vast majority of patients age ≥80 with DCIS in the National Cancer Database received
primary surgical management, which was associated with a significant OS benefit. Considering
comorbidities and patient fitness, surgical resection should be considered for all
patients age ≥80 who are suitable operative candidates.
Keywords
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Article Info
Publication History
Published online: April 21, 2022
Accepted:
April 15,
2022
Received in revised form:
April 14,
2022
Received:
March 10,
2022
Publication stage
In Press Journal Pre-ProofFootnotes
Submitted: Mar 10, 2022; Revised: Apr 14, 2022; Accepted: Apr 15, 2022
Identification
Copyright
© 2022 Elsevier Inc. All rights reserved.
