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Effect of Electroacupuncture Based on ERAS for Preoperative Anxiety in Breast Cancer Surgery: A Single-Center, Randomized, Controlled Trial

  • Qiu-yu Tong
    Affiliations
    Department of Acupuncture, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
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  • Ran Liu
    Affiliations
    Department of Acupuncture, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China

    Institute of Acupuncture and Anesthesia, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
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  • Yuan Gao
    Affiliations
    Department of Acupuncture, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
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  • Kun Zhang
    Affiliations
    Department of Acupuncture, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
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  • Wen Ma
    Correspondence
    Address for correspondence: Wen Ma, MD and Wei-dong Shen, MD, postdoctoral degree, Department of Acupuncture, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
    Affiliations
    Department of Acupuncture, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
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  • Wei-dong Shen
    Correspondence
    Address for correspondence: Wen Ma, MD and Wei-dong Shen, MD, postdoctoral degree, Department of Acupuncture, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
    Affiliations
    Department of Acupuncture, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
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Published:April 29, 2022DOI:https://doi.org/10.1016/j.clbc.2022.04.010

      Highlights

      • EA is potentially valuable addition to ERAS for preoperative anxiety.
      • Preoperative EA alleviated anxiety and improved sleep quality.
      • Combination of pre- and intraoperative EA may improve postoperative quality of life.

      Abstract

      Background

      To evaluate the effect of electroacupuncture (EA) based on enhanced recovery after surgery on preoperative anxiety in patients undergoing breast cancer surgery.

      Patients and Methods

      This was a single-center, randomized, controlled, single-blind clinical trial. Between December 2018 and 2019, 144 female undergoing breast conserving surgery were assigned to conventional (A), preoperative EA (B), intraoperative EA (C), and combination of preoperative and intraoperative EA (D) groups. Primary outcome was the self-rating anxiety scale. Secondary outcomes included visual analogue scale, quality of recovery 40, postoperative complications, and acupuncture-related adverse reactions.

      Results

      141 patients completed the trial. Groups B and D self-rating anxiety scale were significantly lower than A and C (P < .01); the sleep quality was significantly better (P < .01). The incidence of nausea at 6 hours postoperatively was significantly lower in group D than other groups (P < .007); the incidence of vomiting at 6 hours postoperatively was better than group A (P < .007). visual analogue scale at 24 hours postoperatively was significantly different between groups A, B, and D (P < .01). Quality of recovery 40 total score at 24 hours postoperatively in group D was significantly higher than A and B (P < .05). The 72-hour postoperative emotional state was most significantly improved in group D (P < .05), while groups B and C showed interactive effect (P < .05).

      Conclusion

      Preoperative EA alleviated anxiety in the preoperative waiting area, and improved sleep quality. Combination of preoperative and intraoperative EA may be more effective in improving postoperative quality of life.

      Trial registration

      Chinese Clinical Trial Registry, ChiCTR1800019979. Registered on December 10, 2018. (http://www.chictr.org.cn/edit.aspx?pid=27653&htm=4).

      Keywords

      Abbreviations:

      ERAS (Enhanced recovery after surgery), SAS (Self-rating anxiety scale), VAS (Visual Analogue Scale), TCM (Traditional Chinese medicine), PONV (Postoperative nausea and vomiting)
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