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Genetic Variations in IFNGR1, BDNF and IL-10 May Predict the Susceptibility to Depression and Anxiety in Chinese Women With Breast Cancer

  • Author Footnotes
    # BL and DL contributed equally to this study.
    Bo Lan
    Footnotes
    # BL and DL contributed equally to this study.
    Affiliations
    Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
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  • Author Footnotes
    # BL and DL contributed equally to this study.
    Dan Lv
    Footnotes
    # BL and DL contributed equally to this study.
    Affiliations
    Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
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  • Xiaoying Sun
    Affiliations
    Department of Medical Oncology, Cancer Hospital of Huanxing Chaoyang District, Beijing 100122, China
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  • Min Yang
    Affiliations
    Comprehensive Oncology Department, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
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  • Li Zhang
    Affiliations
    National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, China
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  • Fei Ma
    Correspondence
    Address for correspondence: Fei Ma, MD, Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing,100021, China.
    Affiliations
    Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
    Search for articles by this author
  • Author Footnotes
    # BL and DL contributed equally to this study.

      Abstract

      Background

      A large number of breast cancer survivors suffer from psychological distress. The purpose of this study was to investigate the association between genetic variations in Chinese breast cancer patients and anxiety or depression, and to screen patients who are susceptible to psychological problems.

      Methods

      A total of 300 early-stage breast cancer patients were recruited in this prospective observational single-center cohort study. With reference to the previous literature and the mechanism concerning anxiety and depression, 9 candidate genes and 29 single-nucleotide polymorphisms (SNPs) loci were selected. The association between SNP variations and anxiety/depression were analyzed.

      Results

      After we incorporated meaningful clinicopathological and demographic factors, multivariate analysis showed that the A/G and G/G genotypes of IFNGR1 (rs2234711) and the T/C and T/T genotypes of BDNF (rs6265) were significantly associated with depression (HR 3.10, P = .008; HR 2.04, P = .03). The G/A and G/G genotypes of IL-10 (rs1554286) remained independent predictors of anxiety (HR 1.85, P = .019).

      Conclusions

      These findings suggested that variations in IL-10, IFNGR1 and BDNF were associated with anxious/depressive symptoms in early-stage breast cancer patients in China, which could help identify patients at high risk for psychological problems.

      Keywords

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