Abstract
Background
A large number of breast cancer survivors suffer from psychological distress. The
purpose of this study was to investigate the association between genetic variations
in Chinese breast cancer patients and anxiety or depression, and to screen patients
who are susceptible to psychological problems.
Methods
A total of 300 early-stage breast cancer patients were recruited in this prospective
observational single-center cohort study. With reference to the previous literature
and the mechanism concerning anxiety and depression, 9 candidate genes and 29 single-nucleotide
polymorphisms (SNPs) loci were selected. The association between SNP variations and
anxiety/depression were analyzed.
Results
After we incorporated meaningful clinicopathological and demographic factors, multivariate
analysis showed that the A/G and G/G genotypes of IFNGR1 (rs2234711) and the T/C and
T/T genotypes of BDNF (rs6265) were significantly associated with depression (HR 3.10,
P = .008; HR 2.04, P = .03). The G/A and G/G genotypes of IL-10 (rs1554286) remained independent predictors
of anxiety (HR 1.85, P = .019).
Conclusions
These findings suggested that variations in IL-10, IFNGR1 and BDNF were associated
with anxious/depressive symptoms in early-stage breast cancer patients in China, which
could help identify patients at high risk for psychological problems.
Keywords
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Article Info
Publication History
Published online: July 08, 2022
Accepted:
July 1,
2022
Received in revised form:
June 29,
2022
Received:
January 25,
2022
Publication stage
In Press Journal Pre-ProofIdentification
Copyright
© 2022 Elsevier Inc. All rights reserved.
