Abstract
Background
The precise preoperative evaluation of radiologic tumor size with extensive intraductal
component (EIC) is important. This study compared the accuracy of mammography, ultrasound
(US), and magnetic resonance imaging (MRI) to measure invasive breast cancer with
EIC.
Methods
Between 2007 and 2012, we collected data from 6816 patients who underwent surgery
for invasive breast cancer at our institution. We reviewed the postoperative surgical
reports of the tumors, in which the invasive tumor size and EIC were measured separately.
Finally, we included 370 women who underwent preoperative mammography, US, and MRI.
Each modality was retrospectively reviewed to measure the size of invasive breast
cancer with EIC. The reference standard was surgical pathologic size and the accuracies
of the image were evaluated.
Results
Spearman's correlation coefficient for the size of invasive cancer with EIC was good
between MRI (r = 0.741) and pathology, and moderate between mammography (r = 0.661)
or US (r = 0.514) and pathology. Both mass and nonmass lesions showed good correlations
(intraclass correlation coefficient [ICC] = 0.672 and 0.612, respectively) in MRI.
Furthermore, the subgroup of tumors without microcalcifications showed a higher correlation
with MRI (ICC = 0.796) than with mammography (ICC = 0.620). However, the subgroup
with microcalcifications showed a good correlation with mammography (ICC = 0.702)
compared to MRI (ICC = 0.680) and US (ICC = 0.532).
Conclusion
The lesion on mammography, US, and MRI reflected preoperative size of invasive cancer
with EIC. MRI shows a higher correlation than mammography and US. However, cancer
with calcifications of mammography shows a more accurate size than MRI or US.
Keywords
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References
- The presence of an extensive intraductal component following a limited excision correlates with prominent residual disease in the remainder of the breast.J clin Oncol. 1990; 8: 113-118
- Pathologic predictors of early local recurrence in stage I and II breast cancer treated by primary radiation therapy.Cancer. 1984; 53: 1049-1057
- Evolution of breast-conserving therapy for localized breast cancer.J Clin Oncol. 2008; 26: 1395-1396
- Magnetic resonance evaluation of the presence of an extensive intraductal component in breast cancer.Acta Radiologica. 2004; 45: 721-725
- Diagnosis of the intraductal component of invasive breast cancer: assessment with mammography and sonography.J Ultrasound Med. 2007; 26: 1587-1600
- Mammographic features predicting an extensive intraductal component in early-stage infiltrating ductal carcinoma.AJR Am J Roentgenol. 1992; 158: 269-272
- Early breast cancer: predictors of breast recurrence for patients treated with conservative surgery and radiation therapy.Radiother Oncol. 1990; 19: 29-41
- The relationship between microscopic margins of resection and the risk of local recurrence in patients with breast cancer treated with breast-conserving surgery and radiation therapy.Cancer. 1994; 74: 1746-1751
- Diagnostic accuracy of mammography, clinical examination, US, and MR imaging in preoperative assessment of breast cancer.Radiology. 2004; 233: 830-849
- Breast cancer tumor size assessment with mammography, ultrasonography, and magnetic resonance imaging at a community based multidisciplinary breast center.Am Surg. 2012; 78: 440-446
- Mammography, US, and MRI to assess outcomes of invasive breast cancer with extensive intraductal component: a matched cohort study.Radiology. 2019; 292: 299-308
- Imaging features for the prediction of extensive intraductal components in invasive cancer in addition to the histopathologic grades.J Korean Soc Radiol. 2009; 61 ([in Korean]): 413-423
- MR mammography is useful in the preoperative locoregional staging of breast carcinomas with extensive intraductal component.Eur J Radiol. 2007; 62: 273-282
- ACR BI-RADS® Atlas, Breast Imaging Reporting and Data System.American College of Radiology, Reston, VA. 2013;
- The accuracy of breast MR imaging for measuring the size of a breast cancer: analysis of the histopathologic factors.Clin Breast Cancer. 2016; 16: e145-e152
- Social Science Research Design and Statistics: A Practitioner's Guide to Research Methods and IBM SPSS.Watertree Press, Chesapeake, VA2013
- Fundamentals of Biostatistics.6th ed. Thomson-Brooks/Cole, Belmont, CA2006
- Effect of margins on ipsilateral breast tumor recurrence after breast conservation therapy for lymph node-negative breast carcinoma.Cancer. 2004; 100: 1823-1832
- Mammography, US, and MRI for preoperative prediction of extensive intraductal component of invasive breast cancer: interobserver variability and performances.Clin Breast Cancer. 2016; 16: 305-311
- Usefulness of breast MRI for diagnosing an extensive intraductal component of breast cancer: comparison with mammography and ultrasonography.J Korean Radiol Soc. 2006; 54 ([in Korean]): 543-550
- Diagnostic value of mammography for accompanying non-mass enhancement on preoperative breast MRI.Acta Radiol. 2021; 63: 1032-1042
- Identification of preoperative magnetic resonance imaging features associated with positive resection margins in breast cancer: a retrospective study.Korean J Radiol. 2018; 19: 897-904
- Detection of intraductal component around invasive breast cancer using ultrasound: correlation with MRI and histopathological findings.Radiat Med. 2006; 24: 108-114
- Nonmass enhancement on breast MRI: review of patterns with radiologic-pathologic correlation and discussion of management.Am J Roentgenol. 2014; 204: 219-227
- Ductal carcinoma in situ of the breast: MR imaging findings with histopathologic correlation.RadioGraphics. 2010; 30: 1673-1687
- Tumor size and focality in breast carcinoma: analysis of concordance between radiological imaging modalities and pathological examination at a cancer center.Ann Diagn Pathol. 2020; 48151601
- Breast cancer recurrence in the nipple-areola complex after nipple-sparing mastectomy with immediate breast reconstruction for invasive breast cancer.JAMA Surg. 2019; 154: 1030-1037
Article info
Publication history
Published online: October 13, 2022
Accepted:
October 8,
2022
Received in revised form:
October 6,
2022
Received:
February 21,
2022
Identification
Copyright
© 2022 Elsevier Inc. All rights reserved.
