Abstract
Purpose
The accurate determination of human epidermal growth factor receptor 2 (HER2) status
can predict response to treatment with HER2-targeted therapy for HER2-positive breast
cancer patients. [99mTc]Tc-HYNIC-(Ser)3-LTVPWY ([99mTc]Tc-HYNIC-LY) is a small synthetic peptide molecule targeting of the HER2 receptor.
This clinical study evaluated the pharmacokinetic, dosimetry, and efficacy of [99mTc]Tc-HYNIC-LY for determining the HER2 status in primary breast cancer patients.
Materials and Methods
In total, 24 women with suspected primary breast cancer received an intravenous injection
of approximately 20 µg (∼740 MBq) of [99mTc]Tc-HYNIC-LY. In the first 3 patients, blood levels of radioactivity were analyzed
for pharmacokinetic evaluation and planar gamma camera imaging was conducted at 30
min and 1, 2, 4, and 24 hour after injection for dosimetry assessment. In the last
21 patients, planar imaging was performed at the baseline, as well as 1, 2, 3, and
4 hour, followed by single-photon emission computed tomography (SPECT) imaging after
4 hour to evaluate the tumor-targeting potential in primary lesions.
Results
Injection of [99mTc]Tc-HYNIC-LY was safe and well tolerated. Fast blood clearance provided high-contrast
HER2 imaging within 1 to 4 hour. The highest absorbed radiation dose was found for
kidneys (6.78E-03 ± 2.62E-04 mSv/MBq), followed by the heart (3.73E-03 ± 1.98E-04
mSv/MBq). The [99mTc]Tc-HYNIC-LY peptide was able to detect HER2 status in primary tumors at an acceptable
level.
Conclusion
The findings of this study indicated that [99mTc]Tc-HYNIC-LY SPECT is safe and feasible for the identification of HER2-positive
lesions in primary breast cancer patients, and may provide an accurate and non-invasive
modality for guiding HER2 targeted therapy.
Keywords
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Article info
Publication history
Published online: December 08, 2022
Accepted:
December 3,
2022
Received in revised form:
November 27,
2022
Received:
May 25,
2022
Identification
Copyright
© 2022 Elsevier Inc. All rights reserved.
