Abstract
Background
Trastuzumab is an effective therapeutic approach for HER2-positive metastatic breast
cancer (BC). However, a considerable number of patients develop resistance along the
course of the disease. PTEN rs701848 polymorphisms are associated with an increased
risk of developing cancer and have a potential role in predicting drug resistance.
Objective
We studied the significance of PTEN rs701848 variants as significant predictors for
trastuzumab resistance in HER2-positive metastatic BC patients. Therefore, considering
their value in predicting clinical outcomes.
Materials and Methods
This case-control study was conducted among female patients with HER2-positive metastatic
breast cancer who underwent Trastuzumab therapy during the period from March 2017
to December 2020. PTEN rs701848 genotypes were analyzed in 160 HER2-positive metastatic
breast cancer who received Trastuzumab therapy and clinically monitored for therapeutic
response.
Results
PTEN rs701848 is deemed a significant predictor of Trastuzumab resistance and an independent
prognostic factor of progression-free survival (PPFS). In particular, the C allele
is associated with increased risk for Trastuzumab resistance and shorter PFS as compared
to the homozygous TT genotype.
Conclusion
PTEN rs701848 is significant predictor of trastuzumab resistance. Therefore, their
value in predicting clinical outcomes is recommended
Keywords
Abbreviations:
PR (partial remission), SD (stable disease), PD (progressive disease), OS (overall survival), PFS (progression-free survival), OR (odds ratio), HR (hazards ratio), CI (confidence interval), BC (breast cancer), BMI (body mass index), LN (lymph node), PR (progesterone receptors), ER (estrogen receptors)To read this article in full you will need to make a payment
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Article info
Publication history
Published online: December 20, 2022
Accepted:
December 17,
2022
Received in revised form:
December 6,
2022
Received:
September 8,
2022
Identification
Copyright
© 2022 Elsevier Inc. All rights reserved.
