Abstract
Migraine and breast cancer are 2 prevalent diseases with high morbidity and mortality
rates world-wide. There have been inconsistent reports regarding the association between
migraine and risk of breast cancer. This systematic review and meta-analysis aimed
to assess the risk of breast cancer in patients with migraine. By December, 1, 2022,
we searched PubMed, Web of Science, Scopus, and Cochrane Library databases. Odds ratio
(OR), hazard ratio (HR), and 95% confidence intervals (CIs) were extracted or assessed
to determine the pooled risk estimate using a random-effects model. We use the Newcastle-Ottawa
Scale (NOS) to evaluate the quality of studies. We included 9 studies involving 393,282
participants. The pooled analysis showed that patients with migraine had a slightly
low risk of breast cancer (OR 0.82, 95% CI, 0.72-0.94; P = .003), especially in case-control studies (OR 0.69, CI: 0.60-0.81, I2 = 74.1%, p < .001), and hormone receptor-positive breast cancer (OR 0.76, CI: 0.63-0.91; I2 = 88.6%; p = .003). Our findings demonstrate a slightly low risk of breast cancer, especially
hormone receptor-positive breast cancer, in patients with migraine.
Keywords
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to Clinical Breast CancerAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990-2016: a systematic analysis for the Global Burden of Disease Study.Lancet. 2016; 390 (2017): 1211-1259https://doi.org/10.1016/S0140-6736(17)32154-2
- Estrogen, migraine, and vascular risk.Neurol Sci. 2018; 39: 11-20https://doi.org/10.1007/s10072-018-3333-2
- Migraine in postmenopausal women and the risk of invasive breast cancer.Cancer Epidemiol Biomarkers Prev. 2008; 17: 3116-3122https://doi.org/10.1158/1055-9965.EPI-08-0527
- Migraine history and breast cancer risk among postmenopausal women.J Clin Oncol. 2010; 28: 1005-1010https://doi.org/10.1200/JCO.2009.25.0423
- Migraine history and breast cancer risk: a systematic review and meta-analysis.Advances in Breast Cancer Res. 2015; 04: 63-70https://doi.org/10.4236/abcr.2015.43007
- Relationship between migraine history and breast cancer risk among premenopausal and postmenopausal women.Cancer Epidemiol Biomarkers Prev. Jul 2009; 18: 2030-2034https://doi.org/10.1158/1055-9965.EPI-09-0291
- Global cancer statistics.CA Cancer J Clin. 2012; 65: 87-108https://doi.org/10.3322/caac.21262
- The economic burden of physical inactivity: a global analysis of major non-communicable diseases.Lancet. 2016; 388: 1311-1324https://doi.org/10.1016/s0140-6736(16)30383-x
- Cancer statistics.CA Cancer J Clin. 2019; 69: 7-34https://doi.org/10.3322/caac.21551
- Estrogen and cancer.Annu Rev Physiol. 2013; 75: 225-240https://doi.org/10.1146/annurev-physiol-030212-183708
- Migraine and breast cancer risk: a prospective cohort study and meta-analysis.J Natl Cancer Inst. 2015; 107: 381https://doi.org/10.1093/jnci/dju381
- Migraine and subsequent risk of breast cancer: a prospective cohort study.Cancer Causes Control. 2013; 24: 81-89https://doi.org/10.1007/s10552-012-0092-x
- The risk of breast cancer associated with specific patterns of migraine history.Cancer Causes Control. Dec 2014; 25: 1707-1715https://doi.org/10.1007/s10552-014-0479-y
- Evaluation of relationship between breast cancer and migraine.Adv Biomed Res. 2015; 4: 14https://doi.org/10.4103/2277-9175.148297
- Am J Epidemiol. 2010; 171 (S22-): S22
- Association between migraine and breast cancer risk: a population-based cohort study and literature review.J Womens Health (Larchmt). 2018; 27: 1499-1507https://doi.org/10.1089/jwh.2018.6929
- Migraine and breast cancer risk: a meta-analysis of observational studies based on MOOSE compliant.Med (Baltimore). 2016; 95: e4031https://doi.org/10.1097/MD.0000000000004031
- The association between migraine and breast cancer risk: a systematic review and meta-analysis.PLoS One. 2022; 17e0263628https://doi.org/10.1371/journal.pone.0263628
- Hereditary breast cancer: syndromes, tumour pathology and molecular testing.Histopathology. 2023; 82: 70-82https://doi.org/10.1111/his.14808
- Migraine.Nat Rev Dis Primers. 2022; 8: 2https://doi.org/10.1038/s41572-021-00328-4
- Migraine and possible etiologic heterogeneity for hormone-receptor-negative breast cancer.Sci Rep. 2015; 5: 14943https://doi.org/10.1038/srep14943
- Invasive lobular carcinoma of the breast: a special histological type compared with invasive ductal carcinoma.PLoS One. 2017; 12e0182397https://doi.org/10.1371/journal.pone.0182397
- Clinicopathological features and outcomes comparing patients with invasive ductal and lobular breast cancer.J Natl Cancer Inst. 2022; 114: 1511-1522https://doi.org/10.1093/jnci/djac157
- Systemic therapy for estrogen receptor–positive, HER2-negative breast cancer.New England J Med. 2020; 383: 2557-2570https://doi.org/10.1056/NEJMra1307118
- Tracking progesterone receptor-mediated actions in breast cancer.Pharmacol Ther. 2014; 142: 114-125https://doi.org/10.1016/j.pharmthera.2013.11.010
- Treating menopause — MHT and beyond.Natr Rev Endocrinol. 2022; 18: 490-502https://doi.org/10.1038/s41574-022-00685-4
- Migraine.The Lancet. 2018; 391: 1315-1330https://doi.org/10.1016/s0140-6736(18)30478-1
- Chronic migraine: risk factors, mechanisms and treatment.Nat Rev Neurol. 2016; 12: 455-464https://doi.org/10.1038/nrneurol.2016.93
- Migraine treatment: current acute medications and their potential mechanisms of action.Neurotherapeutics. 2018; 15: 274-290https://doi.org/10.1007/s13311-017-0592-1
- Canadian Headache Society Guideline: acute drug therapy for migraine headache.Can J Neurol Sci. 2013; 40 (Suppl 3): S1-s80
- The mechanisms of action of NSAIDs in analgesia.Drugs. 1996; 52 (Suppl): 13-23https://doi.org/10.2165/00003495-199600525-00004
- The effect of NSAIDs exposure on breast cancer risk in female patients with autoimmune diseases.Eur J Cancer Prev. 2019; 28: 428-434https://doi.org/10.1097/cej.0000000000000476
- Aspirin and NSAIDs for breast cancer chemoprevention.Eur J Cancer Prev. 2015; 24: 416-421https://doi.org/10.1097/cej.0000000000000098
- Breast cancer and use of nonsteroidal anti-inflammatory drugs: a meta-analysis.J Natl Cancer Inst. 2008; 100: 1439-1447https://doi.org/10.1093/jnci/djn324
- Aspirin might reduce the incidence of breast cancer: an updated meta-analysis of 38 observational studies.Medicine (Baltimore). 2020; 99: e21917https://doi.org/10.1097/md.0000000000021917
- Breast cancer in China.Lancet Oncol. 2014; 15: e279-e289https://doi.org/10.1016/S1470-2045(13)70567-9
- Collaborative Group on Hormonal Factors in Breast C. Type and timing of menopausal hormone therapy and breast cancer risk: individual participant meta-analysis of the worldwide epidemiological evidence.Lancet. 2019; 394: 1159-1168https://doi.org/10.1016/S0140-6736(19)31709-X
- Recent oral contraceptive use by formulation and breast cancer risk among women 20 to 49 years of age.Cancer Res. 2014; 74: 4078-4089https://doi.org/10.1158/0008-5472.Can-13-3400
- Oral contraceptive use and risk of breast cancer.Mayo Clin Proc. 2008; 83 (86-90quiz): 90-91https://doi.org/10.4065/83.1.86
- Oral contraceptive and breast cancer risks: a case control study in six referral hospitals in Indonesia.Asian Pac J Cancer Prev. 2018; 19: 2199-2203https://doi.org/10.22034/apjcp.2018.19.8.2199
- Alcohol and cancer.Lancet Oncol. 2006; 7: 149-156https://doi.org/10.1016/s1470-2045(06)70577-0
- Alcohol's effects on breast cancer in women.Alcohol Res. 2020; 40: 11https://doi.org/10.35946/arcr.v40.2.11
- Alcohol consumption by beverage type and risk of breast cancer: a dose-response meta-analysis of prospective cohort studies.Alcohol Alcohol. 2020; 55: 246-253https://doi.org/10.1093/alcalc/agaa012
- Active and passive smoking and risk of breast cancer: a meta-analysis.Breast Cancer Res Treat. 2015; 154: 213-224https://doi.org/10.1007/s10549-015-3628-4
- Smoking and risk of breast cancer in the Generations Study cohort.Breast Cancer Res. 2017; 19: 118https://doi.org/10.1186/s13058-017-0908-4
Kelman L. The triggers or precipitants of the acute migraine attack. Cephalalgia. 2007;27:394-402. doi:10.1111/j.1468-2982.2007.01303.x
- Alcohol consumption, cigarette smoking, and familial breast cancer risk: findings from the Prospective Family Study Cohort (ProF-SC).Breast Cancer Res. 2019; 21: 128https://doi.org/10.1186/s13058-019-1213-1
- Pathophysiology of the migraine aura. The spreading depression theory.Brain. 1994; 117: 199-210https://doi.org/10.1093/brain/117.1.199
- Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials.Bmj. 2011; 343: d4002https://doi.org/10.1136/bmj.d4002
Article info
Publication history
Published online: December 24, 2022
Accepted:
December 19,
2022
Received in revised form:
December 12,
2022
Received:
October 18,
2022
Identification
Copyright
© 2022 Elsevier Inc. All rights reserved.
